HSP90B2P

Across TCGA pan-cancer cohorts, HSP90B2P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSP90B2P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HSP90B2P RNA is repressed in tumor relative to normal tissue. In most cancer types HSP90B2P is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, HNSC, and LUAD are the cancer types where HSP90B2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSP90B2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.541	<.001	10	view →
HNSC	Male	II,III,IV	+0.275	<.001	10	view →
LUAD	Male	II,III,IV	+0.414	<.001	9	view →
KIRP	Male	All	−0.330	<.001	9	view →
COAD	Female	II,III,IV	+0.898	<.001	6	view →
KICH	Male	All	−0.430	<.001	6	view →
STAD	All	II,III,IV	+0.405	.003	6	view →
BLCA	All	III,IV	+0.275	.006	5	view →
LUSC	Male	II,III,IV	+0.249	.002	5	view →
CHOL	Male	All	−0.858	<.001	4	view →
PRAD	All	All	+0.144	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSP90B2P–THCA

Open the THCA breakdown →