HSP90B1

Across TCGA patient cohorts, HSP90B1 protein abundance is significantly associated with the RNA expression of many other genes, with 20,076 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HSP90B1-associated genes across cancer lineages are FKBP11, RABGAP1, and BRD3OS. Each is linked with HSP90B1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSP90B1-to-partner and partner-to-HSP90B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSP90B1 versus FKBP11 in CCRCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B1→partner) and Y-score (partner→HSP90B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FKBP11 →	+0.561	+0.378	<.001	<.001	3	8
OV	RABGAP1 →	-0.573	-0.250	.001	.001	3	7
OV	BRD3OS →	-0.578	-0.216	.001	.003	3	7
BRCA	HDAC5 →	-0.494	-0.284	<.001	<.001	3	7
CCRCC	TOX4 →	-0.427	-0.407	<.001	<.001	3	7
HNSC	XBP1 →	+1.098	+0.362	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,076 associations by consensus.

HSP90B1 vs FKBP11 — CCRCC

Explore this scatter interactively →