Across TCGA pan-cancer cohorts, HSFY3P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HSFY3P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HSFY3P RNA is repressed in tumor relative to normal tissue. In most cancer types HSFY3P is over-expressed in tumor, although a few such as KICH and PAAD show the opposite, repressed pattern.

KICH, HNSC, and CHOL are the cancer types where HSFY3P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSFY3P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−0.053	<.001	5	view →
HNSC	Male	All	+0.087	.016	4	view →
CHOL	Male	All	+0.288	.011	2	view →
PAAD	Male	All	−0.080	.015	2	view →
KIRP	Male	All	−0.069	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HSFY3P RNA expression & survival · all HSFY3P data types