HSFY2

Across TCGA patient cohorts, HSFY2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,624 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible HSFY2-associated GO terms across cancer lineages are Methylation, tRNA modification, and Positive regulation of RNA export from nucleus. Each is linked with HSFY2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HSFY2-to-partner and partner-to-HSFY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methylation grouped by HSFY2-low versus HSFY2-high in LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFY2→partner) and Y-score (partner→HSFY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Methylation →	+0.031	+0.006	<.001	<.001	3	6
LUSC	tRNA modification →	+0.029	+0.004	<.001	<.001	3	6
LUSC	Positive regulation of RNA export from nucleus →	+0.031	+0.004	<.001	<.001	3	5
LUSC	Regulation of mRNA splicing, via spliceosome →	+0.043	+0.003	<.001	<.001	3	5
LUSC	rRNA modification →	+0.032	+0.003	<.001	<.001	3	5
LUSC	Positive regulation of amide metabolic process →	+0.036	+0.004	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,624 associations by consensus.

Methylation by HSFY2 expression — LUSC

Explore this box plot interactively →