HSFY2

Across TCGA pan-cancer cohorts, HSFY2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HSFY2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HSFY2 RNA is repressed in tumor relative to normal tissue. In most cancer types HSFY2 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUAD are the cancer types where HSFY2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSFY2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.015	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

HSFY2–LUAD

Open the LUAD breakdown →