HSFY2

Across TCGA cell cohorts, HSFY2 RNA expression is significantly associated with the mutation status of many other genes, with 161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSFY2-associated genes across cancer lineages are MYH8, VARS2, and LRRC66. Each is linked with HSFY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSFY2-to-partner and partner-to-HSFY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH8 grouped by HSFY2-low versus HSFY2-high in BLOOD_Myeloma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFY2→partner) and Y-score (partner→HSFY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYH8 →	+4.807	+0.049	.006	<.001	3	2
STOMACH	VARS2 →	+3.209	+0.030	.007	<.001	3	2
SKIN	LRRC66 →	+4.930	+0.024	.001	<.001	3	2
SKIN	OR5K4 →	+3.345	+0.013	.001	<.001	3	2
LUNG_NSCLC_LUAD	ZNF248 →	+4.371	+0.017	.005	.003	3	2
LUNG_NSCLC_LUAD	TAP2 →	+4.371	+0.033	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

MYH8 by HSFY2 expression — BLOOD_Myeloma

Explore this box plot interactively →