HSFY1P1

Across TCGA patient cohorts, HSFY1P1 mutation is significantly associated with the RNA expression of many other genes, with 383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSFY1P1-associated genes across cancer lineages are RNU6-145P, EEF1A1P39, and SCARNA14. Each is linked with HSFY1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSFY1P1-to-partner and partner-to-HSFY1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-145P grouped by HSFY1P1-low versus HSFY1P1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFY1P1→partner) and Y-score (partner→HSFY1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-145P →	+0.665	+4.392	<.001	.006	3	2
COAD	EEF1A1P39 →	+0.388	+4.324	<.001	.007	3	2
COAD	SCARNA14 →	+0.682	+4.324	.005	.007	3	2
SKCM	OR4F21 →	+0.040	+3.622	.002	.005	3	2
SKCM	MAL2-AS1 →	+0.066	+3.235	.004	.005	3	1
SKCM	CYCSP29 →	+0.098	+3.682	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

RNU6-145P by HSFY1P1 expression — LUSC

Explore this box plot interactively →