HSFY1P1

Across TCGA patient cohorts, HSFY1P1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSFY1P1-associated genes across cancer lineages are Cyclin-B1, Tuberin, and Notch1. Each is linked with HSFY1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSFY1P1-to-partner and partner-to-HSFY1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HSFY1P1-low versus HSFY1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFY1P1→partner) and Y-score (partner→HSFY1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.840	+3.000	.009	.037	3	1
UCEC	Tuberin →	+0.540	+3.009	<.001	.019	2	1
UCEC	Notch1 →	+0.225	+3.000	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Cyclin-B1 by HSFY1P1 expression — UCEC

Explore this box plot interactively →