HSFY1

Across TCGA patient cohorts, HSFY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 655 significant associations in total. OV shows the largest number of these associations.

The most reproducible HSFY1-associated GO terms across cancer lineages are Cerebellar Purkinje cell layer formation, Pyrimidine nucleoside triphosphate metabolic process, and Short-chain fatty acid catabolic process. Each is linked with HSFY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSFY1-to-partner and partner-to-HSFY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cerebellar Purkinje cell layer formation grouped by HSFY1-low versus HSFY1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFY1→partner) and Y-score (partner→HSFY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Cerebellar Purkinje cell layer formation →	+0.051	+0.015	.005	<.001	3	2
LAML	Pyrimidine nucleoside triphosphate metabolic process →	+0.035	+0.009	.001	.001	3	2
COAD	Short-chain fatty acid catabolic process →	+0.066	+0.001	<.001	.001	3	2
LAML	Cellular response to sodium arsenite →	-0.057	-0.010	.003	.002	3	1
LAML	Response to glycoprotein →	+0.052	+0.013	.005	<.001	3	1
LAML	Pyramidal neuron differentiation →	+0.055	+0.012	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 655 associations by consensus.

Cerebellar Purkinje cell layer formation by HSFY1 expression — LAML

Explore this box plot interactively →