HSFY1

Across TCGA pan-cancer cohorts, HSFY1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HSFY1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HSFY1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSFY1 expression acts as an unfavorable survival marker.

UCEC, KIRC, and CESC are the cancer types where HSFY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.193	0.663	<.001	72	view →
KIRC	DFS	Tertile	II,III,IV	0.070	0.762	<.001	36	view →
CESC	OS	Tertile	IV	0.121	0.591	.029	36	view →
HNSC	DFS	Tertile	II,III,IV	0.383	0.699	.020	30	view →
COAD	OS	Tertile	III,IV	0.127	0.800	<.001	27	view →
LUSC	DFS	Tertile	All	0.286	0.648	.029	18	view →
KIRP	DFS	Tertile	II,III,IV	0.157	0.686	.031	18	view →
PAAD	OS	Tertile	All	0.227	0.644	.021	18	view →
READ	OS	Tertile	III,IV	0.328	0.750	.012	18	view →
SARC	DFS	Tertile	All	0.234	0.634	.043	9	view →
ESCA	DFS	Tertile	II,III,IV	0.131	0.776	.043	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HSFY1–UCEC (DFS)

Open the UCEC breakdown →