HSF4

Across TCGA patient cohorts, HSF4 protein abundance is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. OV shows the largest number of these associations.

The most reproducible HSF4-associated genes across cancer lineages are RAB11FIP2, CEP70, and A4GNT. Each is linked with HSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF4-to-partner and partner-to-HSF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSF4 versus RAB11FIP2 in CCRCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF4→partner) and Y-score (partner→HSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RAB11FIP2 →	+0.470	+0.899	.009	.003	3	1
CCRCC	CEP70 →	+0.588	+0.962	.003	.004	3	1
CCRCC	A4GNT →	+1.026	+0.967	.006	.003	3	1
CCRCC	GALNT12 →	+1.049	+1.231	.007	<.001	3	1
CCRCC	MTERF2 →	+0.552	+0.793	.003	.002	3	1
CCRCC	DNAH8 →	+0.285	+0.803	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

HSF4 vs RAB11FIP2 — CCRCC

Explore this scatter interactively →