HSF4

Across TCGA patient cohorts, HSF4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF4-associated genes across cancer lineages are IGFBP2, MAPK_pT202_Y204, and Notch1. Each is linked with HSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF4-to-partner and partner-to-HSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by HSF4-low versus HSF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF4→partner) and Y-score (partner→HSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-1.048	-3.169	.003	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.774	-3.169	.002	.019	3	1
UCEC	Notch1 →	+0.209	+3.169	.006	.020	3	1
UCEC	PRDX1 →	+0.257	+3.000	.023	.036	3	1
UCEC	Annexin-1 →	+0.796	+3.019	.005	.019	3	1
UCEC	VHL →	-1.710	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IGFBP2 by HSF4 expression — UCEC

Explore this box plot interactively →