HSF4

Across TCGA cell cohorts, HSF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,148 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSF4-associated GO terms across cancer lineages are Taurine biosynthetic process, Alkanesulfonate biosynthetic process, and Sperm motility. Each is linked with HSF4 in more than 14 cancer types. Because this analysis shows association rather than direction, both HSF4-to-partner and partner-to-HSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Taurine biosynthetic process grouped by HSF4-low versus HSF4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF4→partner) and Y-score (partner→HSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Taurine biosynthetic process →	+1.018	+1.477	<.001	<.001	3	15
SKIN	Alkanesulfonate biosynthetic process →	+1.018	+1.477	<.001	<.001	3	15
KIDNEY	Sperm motility →	-0.115	-2.333	<.001	<.001	3	14
OVARY	Regulation of sphingolipid biosynthetic process →	+0.107	+1.179	.001	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.108	-1.396	<.001	<.001	3	14
OESOPHAGUS	mRNA splice site recognition →	+0.144	+1.749	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,148 associations by consensus.

Taurine biosynthetic process by HSF4 expression — SKIN

Explore this box plot interactively →