HSF4

Across TCGA cell cohorts, HSF4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSF4-associated genes across cancer lineages are C4orf50, IZUMO1R, and TRIM77. Each is linked with HSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF4-to-partner and partner-to-HSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by HSF4-low versus HSF4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF4→partner) and Y-score (partner→HSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Leukemia	IFNG →	+0.220	+4.152	<.001	.009	3	1
BLOOD_Leukemia	FATE1 →	+0.139	+4.551	<.001	.004	3	1
BLOOD_Leukemia	SERPINA12 →	+0.059	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C4orf50 by HSF4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →