HSF2BP

Across TCGA cell cohorts, HSF2BP mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSF2BP-associated genes across cancer lineages are C20orf85, IL22, and ART1. Each is linked with HSF2BP in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF2BP-to-partner and partner-to-HSF2BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by HSF2BP-low versus HSF2BP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF2BP→partner) and Y-score (partner→HSF2BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	ART1 →	+0.022	+4.705	<.001	.003	3	1
BLOOD_Leukemia	ASZ1 →	+0.140	+4.152	<.001	.009	3	1
BLOOD_Leukemia	GPRC6A →	+0.084	+4.874	<.001	.002	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C20orf85 by HSF2BP expression — BLOOD_Leukemia

Explore this box plot interactively →