HSF2BP

Across TCGA pan-cancer cohorts, HSF2BP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSF2BP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HSF2BP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSF2BP is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where HSF2BP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSF2BP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.808	<.001	12	view →
LUAD	Male	III,IV	+1.481	<.001	11	view →
BLCA	Male	All	+1.268	<.001	10	view →
LIHC	Male	All	+0.560	<.001	8	view →
COAD	Female	II,III,IV	+0.457	<.001	8	view →
LUSC	Female	All	+1.355	<.001	7	view →
BRCA	All	All	+0.623	<.001	6	view →
KIRP	All	II,III,IV	+0.459	<.001	5	view →
STAD	Male	All	+0.556	<.001	4	view →
CHOL	Male	All	+0.966	<.001	3	view →
KICH	Female	All	−0.509	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSF2BP–HNSC

Open the HNSC breakdown →