HSF2BP

Across TCGA cell cohorts, HSF2BP mutation is significantly associated with the mutation status of many other genes, with 95 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSF2BP-associated genes across cancer lineages are HARS2, NEK11, and STK25. Each is linked with HSF2BP in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF2BP-to-partner and partner-to-HSF2BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HARS2 grouped by HSF2BP-low versus HSF2BP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF2BP→partner) and Y-score (partner→HSF2BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HARS2 →	+4.894	+4.894	.004	.004	1	1
BLOOD_Leukemia	NEK11 →	+4.309	+4.560	.007	.007	1	1
BLOOD_Leukemia	STK25 →	+4.894	+4.894	.004	.004	1	1
BLOOD_Leukemia	BCL9 →	+3.157	+4.665	.003	.003	1	1
BLOOD_Leukemia	CHD5 →	+2.572	+4.129	.009	.009	1	1
BLOOD_Leukemia	NT5C1A →	+5.894	+5.321	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

HARS2 by HSF2BP expression — BLOOD_Leukemia

Explore this box plot interactively →