HSDL2

Across TCGA patient cohorts, HSDL2 mutation is significantly associated with the RNA expression of many other genes, with 377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSDL2-associated genes across cancer lineages are RN7SKP42, RNU6-172P, and LINC01853. Each is linked with HSDL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSDL2-to-partner and partner-to-HSDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP42 grouped by HSDL2-low versus HSDL2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSDL2→partner) and Y-score (partner→HSDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP42 →	+0.239	+4.575	<.001	.009	3	2
BLCA	RNU6-172P →	+0.228	+4.685	.003	.007	3	1
BLCA	LINC01853 →	+0.383	+4.899	<.001	.005	3	1
BLCA	MTND1P14 →	+0.056	+4.463	.009	.005	3	1
BLCA	OR6K1P →	+0.035	+4.497	.007	.009	3	1
BLCA	USP12PY →	+0.064	+4.685	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 377 associations by consensus.

RN7SKP42 by HSDL2 expression — BRCA

Explore this box plot interactively →