HSD3BP3

Across TCGA pan-cancer cohorts, HSD3BP3 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HSD3BP3 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HSD3BP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD3BP3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

READ, UCEC, and KIRP are the cancer types where HSD3BP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	III,IV	0.239	0.596	.002	99	view →
UCEC	OS	Tertile	All	0.332	0.729	.002	60	view →
KIRP	DFS	Median	All	0.538	0.653	<.001	56	view →
ESCA	OS	Median	III,IV	0.562	0.319	.016	28	view →
COAD	OS	Tertile	All	0.392	0.608	.005	27	view →
THCA	OS	Tertile	All	0.938	0.994	.008	21	view →
TGCT	OS	Tertile	II,III,IV	0.752	1.000	.019	18	view →
UVM	OS	Quartile	II,III,IV	0.341	0.668	.011	17	view →
MESO	DFS	Median	III,IV	0.210	0.626	.004	15	view →
PCPG	OS	Tertile	All	0.800	0.957	.037	9	view →
CHOL	DFS	Quartile	All	0.160	0.486	.017	8	view →
SKCM	DFS	Quartile	All	0.267	0.169	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HSD3BP3–READ (DFS)

Open the READ breakdown →