HSD3BP3

Across TCGA pan-cancer cohorts, HSD3BP3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HSD3BP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSD3BP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSD3BP3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where HSD3BP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD3BP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.070	.005	6	view →
KICH	Female	All	−0.061	.005	2	view →
THCA	All	All	−0.035	.017	2	view →
CHOL	All	All	+0.185	.041	1	view →
LIHC	Male	II,III,IV	−0.036	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HSD3BP3–KIRC

Open the KIRC breakdown →