Across TCGA pan-cancer cohorts, HSD17B8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HSD17B8 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSD17B8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD17B8 expression acts as an unfavorable survival marker.

HNSC, COAD, and SKCM are the cancer types where HSD17B8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
COAD	OS	Median	All	0.172	0.870	<.001	18	view →
SKCM	DFS	Median	All	0.100	0.728	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HSD17B8 tumor-vs-normal RNA expression · all HSD17B8 data types