Across TCGA patient cohorts, HSD17B8 protein abundance is significantly associated with the RNA expression of many other genes, with 12,392 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HSD17B8-associated genes across cancer lineages are HOGA1, TREM1, and ALPK2. Each is linked with HSD17B8 in more than 6 cancer types. Because this analysis shows association rather than direction, both HSD17B8-to-partner and partner-to-HSD17B8 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B8→partner) and Y-score (partner→HSD17B8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HOGA1 →	+0.779	+0.476	<.001	<.001	3	7
OV	TREM1 →	-0.950	-0.567	.001	<.001	3	6
GBM	ALPK2 →	-1.051	-0.273	<.001	.005	2	7
OV	PLAUR →	-0.850	-0.445	<.001	<.001	3	6
COAD	TUBA1B →	-0.528	-0.250	<.001	<.001	3	6
UCEC	LDHD →	+1.156	+0.396	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,392 associations by consensus.

Exploration

HSD17B8 survival (RNA) · tumor vs normal (RNA) · all HSD17B8 data types