Across TCGA cell cohorts, HSD17B8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,844 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HSD17B8-associated GO terms across cancer lineages are Estrogen biosynthetic process, Negative regulation of amino acid biosynthetic process, and Hormone biosynthetic process. Each is linked with HSD17B8 in more than 11 cancer types. Because this analysis shows association rather than direction, both HSD17B8-to-partner and partner-to-HSD17B8 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B8→partner) and Y-score (partner→HSD17B8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Estrogen biosynthetic process →	+0.192	+1.844	<.001	<.001	3	12
BONE	Negative regulation of amino acid biosynthetic process →	-0.364	-1.904	<.001	<.001	3	8
STOMACH	Hormone biosynthetic process →	+0.116	+1.324	.001	<.001	3	8
BONE	Negative regulation of amino acid metabolic process →	-0.364	-1.904	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.213	-1.689	<.001	<.001	3	8
LARGE_INTESTINE	Protein import into peroxisome matrix →	+0.084	+1.433	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

Exploration

HSD17B8 survival (RNA) · tumor vs normal (RNA) · all HSD17B8 data types