HSD17B7P1

Across TCGA pan-cancer cohorts, HSD17B7P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HSD17B7P1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HSD17B7P1 RNA is repressed in tumor relative to normal tissue. In most cancer types HSD17B7P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, BRCA, and HNSC are the cancer types where HSD17B7P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD17B7P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.382	<.001	7	view →
BRCA	All	All	+0.036	.015	6	view →
HNSC	Male	III,IV	+0.017	.034	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HSD17B7P1–THCA

Open the THCA breakdown →