HSD17B6

Across TCGA patient cohorts, HSD17B6 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B6-associated genes across cancer lineages are MEK1_p_S217_S221, Notch1, and p62 Lck ligand. Each is linked with HSD17B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B6-to-partner and partner-to-HSD17B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by HSD17B6-low versus HSD17B6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B6→partner) and Y-score (partner→HSD17B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	+0.319	+3.000	.026	.036	3	1
UCEC	Notch1 →	+0.296	+3.009	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.357	+3.009	.036	.019	3	1
UCEC	STAT3_pY705 →	-0.428	-3.321	.001	.010	3	1
UCEC	Tuberin →	+0.500	+3.009	<.001	.019	3	1
UCEC	XBP1 →	-0.186	-3.000	.012	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1_p_S217_S221 by HSD17B6 expression — UCEC

Explore this box plot interactively →