HSD17B6

Across TCGA cell cohorts, HSD17B6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B6-associated GO terms across cancer lineages are Regulation of organelle assembly, Negative regulation of cell cycle process, and Cytoplasmic translation. Each is linked with HSD17B6 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSD17B6-to-partner and partner-to-HSD17B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of organelle assembly grouped by HSD17B6-low versus HSD17B6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B6→partner) and Y-score (partner→HSD17B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of organelle assembly →	+0.036	+1.150	.001	<.001	3	9
STOMACH	Negative regulation of cell cycle process →	+0.056	+0.898	<.001	<.001	3	8
PANCREAS	Cytoplasmic translation →	+0.082	+0.589	<.001	<.001	3	8
OESOPHAGUS	Regulation of double-strand break repair via homologous recombination →	+0.096	+1.317	.001	.001	3	8
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.102	+1.006	<.001	<.001	3	8
PANCREAS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.051	+0.516	.004	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

Regulation of organelle assembly by HSD17B6 expression — LUNG_SCLC

Explore this box plot interactively →