HSD17B3

Across TCGA patient cohorts, HSD17B3 mutation is significantly associated with the RNA expression of many other genes, with 1,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B3-associated genes across cancer lineages are UROS, SNORD90, and FAM177A1. Each is linked with HSD17B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B3-to-partner and partner-to-HSD17B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UROS grouped by HSD17B3-low versus HSD17B3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B3→partner) and Y-score (partner→HSD17B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UROS →	+0.463	+3.227	.007	.009	3	2
SKCM	SNORD90 →	+0.135	+3.021	<.001	.009	3	2
UCEC	FAM177A1 →	+0.367	+3.601	.002	.001	3	2
UCEC	WHAMM →	+0.575	+3.031	<.001	<.001	3	2
UCEC	SLC19A1 →	+0.433	+2.673	.003	<.001	3	2
UCEC	ANAPC2 →	+0.446	+3.855	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,680 associations by consensus.

UROS by HSD17B3 expression — SKCM

Explore this box plot interactively →