HSD17B3

Across TCGA pan-cancer cohorts, HSD17B3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HSD17B3 data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HSD17B3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HSD17B3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

SKCM, LGG, and KICH are the cancer types where HSD17B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	III,IV	0.599	0.287	<.001	56	view →
LGG	DFS	Median	All	0.636	0.832	<.001	54	view →
KICH	OS	Tertile	III,IV	0.585	1.000	.007	44	view →
KIRC	DFS	Tertile	All	0.526	0.681	.004	28	view →
STAD	OS	Median	All	0.488	0.341	.006	24	view →
PAAD	OS	Median	All	0.621	0.353	.003	24	view →
PRAD	DFS	Median	All	0.828	0.939	<.001	18	view →
KIRP	DFS	Tertile	All	0.777	0.925	.004	15	view →
ACC	OS	Tertile	IV	0.871	0.370	.001	12	view →
BLCA	DFS	Tertile	IV	0.605	0.350	.006	12	view →
READ	OS	Quartile	III,IV	0.857	0.548	.017	12	view →
PCPG	DFS	Tertile	All	0.911	0.634	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HSD17B3–SKCM (OS)

Open the SKCM breakdown →