HSD17B3

Across TCGA cell cohorts, HSD17B3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,524 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B3-associated GO terms across cancer lineages are Cellular response to steroid hormone stimulus, Regulation of syncytium formation by plasma membrane fusion, and Cellular response to nutrient levels. Each is linked with HSD17B3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSD17B3-to-partner and partner-to-HSD17B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to steroid hormone stimulus grouped by HSD17B3-low versus HSD17B3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B3→partner) and Y-score (partner→HSD17B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cellular response to steroid hormone stimulus →	+0.070	+0.395	.004	.001	3	9
LARGE_INTESTINE	Regulation of syncytium formation by plasma membrane fusion →	+0.038	+0.399	.005	<.001	3	7
STOMACH	Cellular response to nutrient levels →	+0.088	+0.664	<.001	.001	3	6
STOMACH	Glycerophospholipid biosynthetic process →	+0.062	+0.581	<.001	.006	3	6
STOMACH	Cilium movement involved in cell motility →	-0.075	-0.340	.001	.003	3	6
STOMACH	Phospholipid biosynthetic process →	+0.052	+0.555	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,524 associations by consensus.

Cellular response to steroid hormone stimulus by HSD17B3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →