HSD17B3

Across TCGA cell cohorts, HSD17B3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSD17B3-associated genes across cancer lineages are SIGLEC8, PRY, and PRY2. Each is linked with HSD17B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B3-to-partner and partner-to-HSD17B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by HSD17B3-low versus HSD17B3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B3→partner) and Y-score (partner→HSD17B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRY →	+0.023	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY2 →	+0.023	+5.228	<.001	.005	3	1
LARGE_INTESTINE	NPHS2 →	+0.075	+3.444	.003	.003	3	1
LARGE_INTESTINE	RBM46 →	+0.210	+3.994	<.001	.002	3	1
LARGE_INTESTINE	AGRP →	+0.146	+3.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SIGLEC8 by HSD17B3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →