HSD17B2

Across TCGA patient cohorts, HSD17B2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,210 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HSD17B2-associated genes across cancer lineages are SLC9A2, REC8, and CYP3A5. Each is linked with HSD17B2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSD17B2-to-partner and partner-to-HSD17B2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD17B2 versus SLC9A2 in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B2→partner) and Y-score (partner→HSD17B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC9A2 →	+1.119	+0.541	.003	.003	3	4
UCEC	REC8 →	-1.095	-0.462	.008	.005	2	4
LUAD	CYP3A5 →	+1.848	+1.823	<.001	<.001	3	3
LUAD	DNMT1 →	-0.695	-1.642	<.001	<.001	3	3
UCEC	GIPC2 →	+1.448	+0.615	<.001	<.001	3	3
LUAD	TSPAN1 →	+2.064	+1.424	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,210 associations by consensus.

HSD17B2 vs SLC9A2 — UCEC

Explore this scatter interactively →