HSD17B2

Across TCGA patient cohorts, HSD17B2 mutation is significantly associated with the RNA expression of many other genes, with 985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B2-associated genes across cancer lineages are ZNF57, C15orf61, and POLE2. Each is linked with HSD17B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD17B2-to-partner and partner-to-HSD17B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF57 grouped by HSD17B2-low versus HSD17B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B2→partner) and Y-score (partner→HSD17B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF57 →	+0.452	+2.711	.002	.003	3	3
UCEC	C15orf61 →	+0.504	+3.584	<.001	.002	3	3
UCEC	POLE2 →	+0.710	+2.721	<.001	.003	3	2
UCEC	AHSA1 →	+0.501	+3.467	.001	.002	3	2
UCEC	DHRS2 →	+1.312	+3.828	<.001	<.001	3	2
UCEC	SGTA →	+0.505	+2.523	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 985 associations by consensus.

ZNF57 by HSD17B2 expression — UCEC

Explore this box plot interactively →