HSD17B14

Across TCGA patient cohorts, HSD17B14 protein abundance is significantly associated with the RNA expression of many other genes, with 3,400 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSD17B14-associated genes across cancer lineages are FCGR2B, TREM1, and ALKBH1. Each is linked with HSD17B14 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSD17B14-to-partner and partner-to-HSD17B14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD17B14 versus FCGR2B in GBM, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B14→partner) and Y-score (partner→HSD17B14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR2B →	+1.028	+0.587	<.001	<.001	3	4
GBM	TREM1 →	+1.228	+0.566	.002	.001	3	3
PDAC	ALKBH1 →	-0.534	-0.724	<.001	<.001	3	2
PDAC	SGCA →	+0.909	+0.491	.005	.008	3	2
LSCC	TTLL5 →	-0.507	-0.406	<.001	<.001	3	2
LSCC	SLIRP →	-0.595	-0.437	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,400 associations by consensus.

HSD17B14 vs FCGR2B — GBM

Explore this scatter interactively →