HSD17B14

Across TCGA pan-cancer cohorts, HSD17B14 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HSD17B14 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher HSD17B14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD17B14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UVM, HNSC, and LUAD are the cancer types where HSD17B14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.395	0.785	<.001	91	view →
HNSC	DFS	Median	IV	0.413	0.213	<.001	59	view →
LUAD	OS	Quartile	II,III,IV	0.839	0.612	<.001	55	view →
UCEC	DFS	Quartile	II,III,IV	0.701	0.885	.004	40	view →
SARC	DFS	Median	All	0.440	0.225	<.001	35	view →
CESC	OS	Median	III,IV	0.537	0.204	.015	34	view →
STAD	OS	Quartile	All	0.454	0.691	.001	31	view →
COAD	DFS	Quartile	All	0.555	0.724	.003	29	view →
ACC	DFS	Quartile	All	0.981	0.578	.006	27	view →
KICH	DFS	Median	III,IV	0.373	1.000	.009	26	view →
PAAD	OS	Tertile	All	0.581	0.379	.002	26	view →
UCS	DFS	Tertile	IV	0.364	0.936	.024	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HSD17B14–UVM (DFS)

Open the UVM breakdown →