HSD17B14

Across TCGA patient cohorts, HSD17B14 mutation is significantly associated with the RNA expression of many other genes, with 415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B14-associated genes across cancer lineages are SEPTIN14P19, MIR3143, and RBM22P6. Each is linked with HSD17B14 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B14-to-partner and partner-to-HSD17B14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by HSD17B14-low versus HSD17B14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B14→partner) and Y-score (partner→HSD17B14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN14P19 →	+0.025	+3.923	<.001	.009	3	2
COAD	MIR3143 →	+0.823	+3.373	<.001	.004	3	2
SKCM	RBM22P6 →	+0.096	+5.594	<.001	.004	3	1
UCEC	MIR3127 →	+0.349	+2.429	<.001	.007	3	1
UCEC	MIR4516 →	+0.391	+2.678	<.001	.003	3	1
UCEC	TTLL12 →	+0.838	+3.330	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 415 associations by consensus.

SEPTIN14P19 by HSD17B14 expression — UCEC

Explore this box plot interactively →