HSD17B14

Across TCGA patient cohorts, HSD17B14 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B14-associated genes across cancer lineages are 4E-BP1_pT70, c-Met_pY1235, and p70-S6K_pT389. Each is linked with HSD17B14 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B14-to-partner and partner-to-HSD17B14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by HSD17B14-low versus HSD17B14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B14→partner) and Y-score (partner→HSD17B14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.157	+3.321	.009	.010	3	2
UCEC	c-Met_pY1235 →	+0.094	+3.009	.015	.019	3	2
UCEC	p70-S6K_pT389 →	-0.281	-3.321	.004	.010	3	1
UCEC	PCNA →	+0.490	+3.169	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.393	-3.159	.004	.019	3	1
UCEC	C-Raf →	+0.329	+3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

4E-BP1_pT70 by HSD17B14 expression — UCEC

Explore this box plot interactively →