HSD17B14

Across TCGA cell cohorts, HSD17B14 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B14-associated genes across cancer lineages are GML, LRIT1, and GPR26. Each is linked with HSD17B14 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B14-to-partner and partner-to-HSD17B14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by HSD17B14-low versus HSD17B14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B14→partner) and Y-score (partner→HSD17B14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LRIT1 →	+0.046	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GPR26 →	+0.057	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1L3 →	+0.085	+4.276	<.001	.007	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.067	+4.276	<.001	.007	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GML by HSD17B14 expression — BLOOD_Leukemia

Explore this box plot interactively →