HSD17B12

Across TCGA patient cohorts, HSD17B12 mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B12-associated genes across cancer lineages are RNA5SP51, MIR153-1, and ZBTB8OS. Each is linked with HSD17B12 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD17B12-to-partner and partner-to-HSD17B12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP51 grouped by HSD17B12-low versus HSD17B12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B12→partner) and Y-score (partner→HSD17B12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP51 →	+0.154	+4.900	<.001	.002	3	3
CESC	MIR153-1 →	+0.408	+5.418	<.001	.005	3	2
UCEC	ZBTB8OS →	+0.392	+3.201	.001	.009	3	2
UCEC	TUBGCP5 →	+0.428	+3.332	.006	.005	3	2
UCEC	ATP6V1D →	+0.473	+2.906	.002	.002	3	2
UCEC	COPS7A →	+0.350	+3.387	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

RNA5SP51 by HSD17B12 expression — SKCM

Explore this box plot interactively →