HSD17B10

Across TCGA patient cohorts, HSD17B10 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B10-associated genes across cancer lineages are MEK1, mTOR, and Notch1. Each is linked with HSD17B10 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B10-to-partner and partner-to-HSD17B10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HSD17B10-low versus HSD17B10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B10→partner) and Y-score (partner→HSD17B10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.516	+3.321	.003	.010	3	1
UCEC	mTOR →	-0.187	-2.459	.016	.020	3	1
UCEC	Notch1 →	+0.178	+3.009	.008	.019	3	1
UCEC	Rictor_pT1135 →	-0.101	-2.459	.042	.020	3	1
UCEC	STAT3_pY705 →	-0.402	-2.311	.001	.034	3	1
UCEC	Tuberin →	+0.334	+2.179	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by HSD17B10 expression — UCEC

Explore this box plot interactively →