HSD17B10

Across TCGA pan-cancer cohorts, HSD17B10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HSD17B10 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher HSD17B10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HSD17B10 expression acts as an unfavorable survival marker, although some lineages such as CESC and THCA show a favorable association.

KICH, LGG, and BRCA are the cancer types where HSD17B10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	All	0.329	1.000	.003	86	view →
LGG	OS	Median	All	0.731	0.888	<.001	48	view →
BRCA	OS	Tertile	All	0.944	0.975	.002	44	view →
LAML	DFS	Tertile	All	0.386	0.703	<.001	36	view →
CESC	OS	Quartile	All	0.748	0.395	<.001	32	view →
UVM	OS	Median	All	0.407	0.799	.004	30	view →
THCA	DFS	Median	All	0.907	0.775	.001	27	view →
KIRC	DFS	Median	II,III,IV	0.610	0.362	.006	20	view →
ESCA	DFS	Quartile	All	0.317	0.565	.002	18	view →
SCLC	OS	Quartile	All	0.848	0.558	.009	14	view →
ACC	DFS	Quartile	All	0.254	0.702	.007	13	view →
SKCM	OS	Median	All	0.252	0.376	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HSD17B10–KICH (OS)

Open the KICH breakdown →