HSD11B2

Across TCGA patient cohorts, HSD11B2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,524 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HSD11B2-associated genes across cancer lineages are SELENBP1, PAQR8, and CD274. Each is linked with HSD11B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD11B2-to-partner and partner-to-HSD11B2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD11B2 versus SELENBP1 in LUAD, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B2→partner) and Y-score (partner→HSD11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SELENBP1 →	+1.381	+0.833	<.001	.001	3	3
PDAC	PAQR8 →	+0.869	+0.713	.001	<.001	3	3
HNSC	CD274 →	-1.028	-0.591	.001	.002	3	3
COAD	APOL1 →	-0.802	-0.464	.001	<.001	3	2
COAD	AQP9 →	-0.978	-0.453	<.001	<.001	3	2
UCEC	SOD2 →	-0.608	-0.446	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,524 associations by consensus.

HSD11B2 vs SELENBP1 — LUAD

Explore this scatter interactively →