HSD11B2

Across TCGA pan-cancer cohorts, HSD11B2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HSD11B2 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HSD11B2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD11B2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

ACC, UVM, and KIRC are the cancer types where HSD11B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.212	0.704	<.001	134	view →
UVM	OS	Median	All	0.415	0.829	<.001	133	view →
KIRC	DFS	Median	All	0.714	0.545	<.001	130	view →
OV	DFS	Median	III,IV	0.196	0.117	.001	46	view →
KICH	OS	Median	II,III,IV	0.964	0.623	.002	45	view →
SKCM	OS	Tertile	All	0.730	0.852	<.001	45	view →
GBM	OS	Median	All	0.562	0.265	<.001	24	view →
HNSC	DFS	Quartile	IV	0.830	0.582	.002	20	view →
PAAD	OS	Median	All	0.469	0.686	.003	18	view →
LIHC	DFS	Median	All	0.469	0.631	.003	17	view →
KIRP	OS	Tertile	II,III,IV	0.377	0.736	.004	17	view →
STAD	DFS	Median	II,III,IV	0.695	0.583	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HSD11B2–ACC (DFS)

Open the ACC breakdown →