HSD11B2

Across TCGA patient cohorts, HSD11B2 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD11B2-associated genes across cancer lineages are RNU6-340P, RNU6-362P, and MIR8053. Each is linked with HSD11B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B2-to-partner and partner-to-HSD11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-340P grouped by HSD11B2-low versus HSD11B2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B2→partner) and Y-score (partner→HSD11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-340P →	+0.363	+7.741	<.001	.009	3	2
HNSC	RNU6-362P →	+0.363	+7.954	<.001	.008	3	2
SKCM	MIR8053 →	+0.516	+6.328	<.001	.001	3	2
HNSC	TSPY7P →	+0.039	+7.954	<.001	.008	3	1
UCEC	SLC25A4 →	+0.602	+3.332	.009	.005	3	1
UCEC	DDX19A →	+0.557	+3.343	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

RNU6-340P by HSD11B2 expression — COAD

Explore this box plot interactively →