HSD11B2

Across TCGA patient cohorts, HSD11B2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD11B2-associated genes across cancer lineages are EGFR_pY1068, Annexin-1, and STAT3_pY705. Each is linked with HSD11B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B2-to-partner and partner-to-HSD11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HSD11B2-low versus HSD11B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B2→partner) and Y-score (partner→HSD11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.322	-3.169	.019	.020	3	1
UCEC	Annexin-1 →	+0.921	+3.019	.001	.019	3	1
UCEC	STAT3_pY705 →	-0.531	-3.169	<.001	.020	3	1
UCEC	ATM →	-0.781	-3.169	.001	.020	3	1
UCEC	p70-S6K_pT389 →	-0.290	-3.160	.005	.019	2	1
UCEC	Shc_pY317 →	-0.285	-3.169	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by HSD11B2 expression — UCEC

Explore this box plot interactively →