HSD11B2

Across TCGA cell cohorts, HSD11B2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,261 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HSD11B2-associated GO terms across cancer lineages are Cortisol metabolic process, Regulation of plasminogen activation, and T-helper cell lineage commitment. Each is linked with HSD11B2 in more than 17 cancer types. Because this analysis shows association rather than direction, both HSD11B2-to-partner and partner-to-HSD11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cortisol metabolic process grouped by HSD11B2-low versus HSD11B2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B2→partner) and Y-score (partner→HSD11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cortisol metabolic process →	+1.755	+2.428	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of plasminogen activation →	-0.273	-1.643	<.001	<.001	3	13
LUNG_NSCLC_LUSC	T-helper cell lineage commitment →	-0.190	-1.465	.001	<.001	3	12
URINARY_TRACT	Desmosome organization →	+0.293	+1.200	<.001	.005	3	12
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.235	-1.622	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cell surface receptor signaling pathway via STAT →	-0.098	-1.987	.001	.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,261 associations by consensus.

Cortisol metabolic process by HSD11B2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →