HSD11B2

Across TCGA cell cohorts, HSD11B2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSD11B2-associated genes across cancer lineages are ENPP6, FAM205A, and C14orf177. Each is linked with HSD11B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B2-to-partner and partner-to-HSD11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP6 grouped by HSD11B2-low versus HSD11B2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B2→partner) and Y-score (partner→HSD11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.040	+3.793	.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
BLOOD_Leukemia	C14orf177 →	+0.114	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ENPP6 by HSD11B2 expression — LARGE_INTESTINE

Explore this box plot interactively →