HSCB

Across TCGA pan-cancer cohorts, HSCB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HSCB data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HSCB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSCB expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where HSCB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.296	0.933	<.001	34	view →
LUAD	OS	Tertile	All	0.589	0.892	.006	22	view →
HNSC	OS	Tertile	III,IV	0.759	0.988	<.001	14	view →
GBM	DFS	Tertile	All	0.579	0.259	.006	11	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
UCEC	OS	Tertile	All	0.968	0.831	.035	4	view →
LSCC	DFS	Quartile	III,IV	0.789	0.302	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HSCB–CCRCC (DFS)

Open the CCRCC breakdown →