HSCB

Across TCGA patient cohorts, HSCB protein abundance is significantly associated with the RNA expression of many other genes, with 8,867 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HSCB-associated genes across cancer lineages are ZNRF3, BTN2A1, and RNASEH2C. Each is linked with HSCB in more than 3 cancer types. Because this analysis shows association rather than direction, both HSCB-to-partner and partner-to-HSCB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSCB versus ZNRF3 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSCB→partner) and Y-score (partner→HSCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNRF3 →	+0.760	+0.319	<.001	.002	3	4
LUAD	BTN2A1 →	-0.410	-0.321	<.001	<.001	3	4
COAD	RNASEH2C →	-0.586	-0.303	<.001	.003	3	4
COAD	FAM32A →	-0.392	-0.220	<.001	.002	3	4
BRCA	TWF2 →	-0.524	-0.302	.002	.003	3	4
OV	GIPC1 →	-0.728	-0.290	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,867 associations by consensus.

HSCB vs ZNRF3 — HNSC

Explore this scatter interactively →