HSCB

Across TCGA cell cohorts, HSCB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSCB-associated GO terms across cancer lineages are Primitive hemopoiesis, [2Fe-2S] cluster assembly, and Embryonic hemopoiesis. Each is linked with HSCB in more than 19 cancer types. Because this analysis shows association rather than direction, both HSCB-to-partner and partner-to-HSCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Primitive hemopoiesis grouped by HSCB-low versus HSCB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSCB→partner) and Y-score (partner→HSCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Primitive hemopoiesis →	+0.190	+0.931	<.001	<.001	3	20
URINARY_TRACT	[2Fe-2S] cluster assembly →	+0.132	+0.722	<.001	.001	2	14
LUNG_NSCLC_LUAD	Embryonic hemopoiesis →	+0.140	+0.559	<.001	<.001	3	11
URINARY_TRACT	Iron-sulfur cluster assembly →	+0.102	+0.675	<.001	.001	2	12
URINARY_TRACT	Metallo-sulfur cluster assembly →	+0.102	+0.675	<.001	.001	2	12
BONE	DNA replication proofreading →	-0.218	-1.019	.007	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,235 associations by consensus.

Primitive hemopoiesis by HSCB expression — BONE

Explore this box plot interactively →