HS6ST2

Across TCGA cell cohorts, HS6ST2 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS6ST2-associated genes across cancer lineages are RESP18, FAM149A, and FANCE. Each is linked with HS6ST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS6ST2-to-partner and partner-to-HS6ST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by HS6ST2-low versus HS6ST2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST2→partner) and Y-score (partner→HS6ST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1
LARGE_INTESTINE	FAM149A →	+1.290	+3.364	.001	.002	3	1
LARGE_INTESTINE	FANCE →	+0.480	+3.169	.005	.009	3	1
LARGE_INTESTINE	RPS12 →	+0.643	+3.169	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.000	<.001	.003	3	1
LARGE_INTESTINE	GALR3 →	+0.109	+3.839	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

RESP18 by HS6ST2 expression — OVARY

Explore this box plot interactively →